Efeito protetor do treinamento físico aeróbico no estresse oxidativo causado por material particulado em ratos
Resumo
Introdução: O material particulado (MP) é um poluente atmosférico associado a efeitos deletérios à saúde. Dentre estes efeitos, está o estresse oxidativo, que pode resultar desde uma resposta inflamatória local até danos sistêmicos ao organismo. Alguns estudos apontam que quando o indivíduo é submetido a treinamento físico aeróbico, gera efeito protetor antioxidante que supera os malefícios gerados pelo MP. Objetivo: Assim, o objetivo do estudo visou avaliar a influência do material particulado MP2,5 e MP10 no estresse oxidativo. Métodos: A avaliação da influência do MP nos parâmetros do estresse oxidativo foram realizados através de dosagens de superóxido dismutase, catalase, glutationa peroxidase e poder antioxidante total em ratos Wistar machos não expostos ao material particulado, com e sem treinamento físico aeróbico e expostos ao material particulado MP2,5 e MP10, com e sem treinamento físico aeróbico. Este protocolo teve a duração de cinco semanas. Resultados: As enzimas antioxidantes analisadas que apresentaram uma diferença significativa foram a catalase e a glutationa peroxidase. Conclusões: A partir desta pesquisa foi possível perceber que o MP influência negativamente no estresse oxidativo e no peso corporal dos ratos e que o exercício aeróbico gera efeito protetor contra estes danos.
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