O treinamento de resistência reverte a resistência à insulina de ratos com periodontitis
Resumo
O objetivo do presente estudo foi avaliar os efeitos do treinamento de resistência (TR) na glicemia, insulinemia, sensibilidade à insulina, sinalização à insulina (SI) e níveis de fator de necrose tumoral-α (TNF-α) em ratos com periodontite. 40 ratos Wistar machos foram distribuidos em 4 grupos: grupo controle sedentário (SCN), grupo controle exercitado (ExCN), grupo doença periodontal induzida por ligadura sedentária (SPD) e grupo doença periodontal induzida por ligadura exercitada (ExPD). 28 dias após a indução da periodontite iniciou a RT (14 semanas). Glicemia, insulina, níveis de TNF-α e sensibilidade à insulina foram analisados usando vários métodos. IS foi avaliado medindo pp185 com tirosina fosforilada em tecidos sensíveis à insulina (método de western blot). Níveis mais elevados de insulina, HOMA-IR e TNF-α e diminuição da sensibilidade à insulina foram observados no grupo SPD, que também apresentou diminuição dos níveis de tirosina fosforilada por insulina estimulada em pp185 no músculo e tecido adiposo, quando comparado aos outros grupos. O grupo ExPD apresentou níveis aumentados de pp185 tirosina fosforilada estimulada por insulina em comparação ao grupo SPD, mas não apresentou diferença significativa quando comparado aos grupos SCN e ExCN. A RT reverteu as alterações de RI e SI em ratos com periodontite induzida e também diminuiu os níveis de insulina e TNF-α. Portanto, os resultados mostram a importância do TR na prevenção ou reversão da RI em ratos com periodontite.
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